The reported range in sensitivity of an elevated GGT for detecting alcohol ingestion is 52-94%,Serum GGT levels are elevated both in obese individuals and in those with type 2 diabetes, but especially when these two conditions are combined, as is often the case.Note that if the patient has no riskfactors, or if symptoms and physical examination are unremarkable, an isolated GGT elevation requires no further investigation or referral. Some authorities have advocated the use of GGT to identify patients with occult alcohol abuse. Abstract: Gamma-glutamyltransferase (GGT) is a highly sensitive but poorly specific liver enzyme commonly used to detect hepatobiliary dis- ease and possible alcohol abuse.

Name must be less than 100 characters This site needs JavaScript to work properly. In a retrospective study of 158 epileptics, the mean values of the serum gamma GT level have been … His body mass index (BMI) is 32, and his diabetes is currently being managed with diet and metformin.

PMID: 1347005 [PubMed - indexed for MEDLINE] Publication Types: Case Reports; MeSH Terms. He is otherwise generally well. Tests for gamma-glutamyl transferase (GGT) are important in the diagnosis of liver/biliary tract disease and useful in identifying alcohol abuse.

The liver profile need not be repeated, nor any medications stopped.The abnormality on the liver profile should be discussed with the patient, and this might be a good time to ask again about their alcohol consumption, and to suggest moderating their intake. Lieberman D, Phillips D. “Isolated” elevation of alkaline phosphatase: significance in hospitalized patients. Adult; Chronic Disease; Clinical Enzyme Tests*

His only other medication is simvastatin 20mg, which he has taken for the past 4 years. The findings concerning the correlation between this elevation of gamma GT and various dimensions of epilepsy or treatment regimens are equivocal. Your results will be in international units per liter, or IU/L. Isolated GGT elevation is common and generally does not indicate serious or progressive liver disease unless there are risk factors, symptoms or physical abnormalities. Unable to load your delegates due to an error Gamma-glutamyl transferase (GGT) is a cell surface enzyme.

The gamma-glutamyl transferase (GGT) test may be used to determine the cause of elevated alkaline phosphatase (ALP).Both ALP and GGT are elevated in disease of the bile ducts and in some liver diseases, but only ALP will be elevated in bone disease.Therefore, if the GGT level is normal in a person with a high ALP, the cause of the elevated ALP is most likely bone disease. Latent elevations in GGT are typically seen in patients with chronic viral hepatitis infections often taking 12 months or more to present.

COVID-19 is an emerging, rapidly evolving situation. [Article in German] Weber P(1), Dölle W. Author information: (1)Abteilung Innere Medizin I, Medizinische Universitätsklinik und Poliklinik, Tübingen. However, the GGT can help distinguish whether an elevated alkaline phosphatase is of liver or bone origin.

[An isolated elevation of gamma-GT]. A 45-year-old man attends surgery for review of his type 2 diabetes of 6 years’ duration.

Read on to learn more about the function of GGT, its health effects, and ways to lower GGT levels.

GGT is predominantly used as a diagnostic marker for liver disease.

Its usefulness as a marker of alcohol abuse is overrated, as the differential diagnosis of a high GGT is so broad.

Clipboard, Search History, and several other advanced features are temporarily unavailable. Cleve Clin J Med 2010; 77: 195-204. Please enable it to take advantage of the complete set of features! OpenUrl PubMed ↵ Aragon G, Younossi Z. Unable to load your collection due to an error

His stated alcohol consumption, unchanged recently, is approximately10 units per week.You review his results and note that he has an elevated gamma-glutamyl transpeptidase (GGT) level of 132 IU/l (normal level is What is GGT?

Making a referral to a dietician is quite important. In adults, GGT levels in the range of 0 to 30 IU/L are normal. Penev P, Penev M, Georgiev I, Popov G, Dukova-Peneva P. When and how to evaluate mildly elevated liver enzymes in apparently healthy patients.