Skeie WLOsserman ABarlow Bach
et al Myasthenia gravis: measurement of anti-AChR autoantibodies using cell line TE671. VA Thymic B lymphocyte clones from patients with myasthenia gravis secrete monoclonal striational autoantibodies reacting with myosin, alpha actinin, or actin. These clinical correlations should prompt further studies to examine the mechanisms leading to the production of anti-titin antibodies.© 2020 American Medical Association. DD Antibody to acetylcholine receptor in myasthenia gravis: prevalence, clinical correlates, and diagnostic value. Williams
Comment
Comparison of their clinical features showed that thymoma was present among anti-titin–positive, ASMA-negative patients but not in anti-titin–negative, ASMA-positive patients, who instead shared features with anti-titin–negative patients. NE Titin antibodies in patients with late onset myasthenia gravis: clinical correlations. All Rights ReservedTitin is the major autoantigen recognized by anti–striated muscle antibodies, which are characteristic of generalized myasthenia gravis (MG).To seek a correlation between anti-titin antibodies and other features of MG patients, including histopathology, age at diagnosis, anti–acetylcholine receptor (anti-AChR), autoantibody titers, and clinical severity.A novel, highly specific radioligand assay was performed on a large group of 398 patients with generalized MG.Among thymectomized patients, anti-titin antibodies were present in most patients with thymoma (56/70 [80%]), contrasting with only a minority of patients with thymus atrophy or hyperplasia (17/165 [10%]).
et al Titin antibodies in myasthenia gravis: identification of a major immunogenic region of titin.
Correlation Between Anti-Titin Antibodies and Anti−Striated Muscle Antibodies (ASMAs)*Table 5.
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VA Paraneoplastic IgG striational autoantibodies produced by clonal thymic B cells and in serum of patients with myasthenia gravis and thymoma react with titin. SDuane Shipping charges listed below are from our US warehouses to the Contiguous US, Yamamoto SDuane Patients ALaureti 0 Items in your shopping cart Their presence showed a high correlation with the results of ASMA immunofluorescence tests (Altogether, both anti-titin antibodies and ASMAs had a good predictive value for the presence of thymoma, particularly in subjects 60 years of age or younger (The identification and use of molecularly defined antigens are essential to a better understanding of the complexity of autoimmune responses.
In humans, this protein is encoded by the gene TTN. Voltz
NE Anti-cardiac ryanodine receptor antibodies in thymoma-associated myasthenia gravis. Anti-titin occurs in absence of myasthenia gravis and thymoma.Anti-titin occurs in absence of myopathy and cardiac disease.Anti-titin antibodies indicate a paraneoplastic etiology pointing towards a thymoma in myasthenia gravis (MG), but their seroprevalence and potential diagnostic value in patients with other paraneoplastic neurological syndromes (PNS) is unknown. This method is used for less temperature sensitive items such as lab ware and animal
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JMSeybold AJSeegal
RDAlbrich WCNagele
Titin is a giant protein, greater than 1 µm in length, that functions as a molecular spring which is responsible for the passive elasticity of muscle in addition to keeping myosin molecules in place.
Showing 18 of 18 suppliers (100 products total) > >> Select All. H indicates hyperplasia; A, atrophy; and T, thymoma.Nonthymoma patients with anti-titin antibodies form a homogeneous group with a late age at onset of disease and intermediate titers of anti–acetylcholine receptor (anti-AChR) autoantibodies.Customize your JAMA Network experience by selecting one or more topics from the list below.Yamamoto AM, Gajdos P, Eymard B, et al. DJ Diagnosis of thymoma in myasthenics using anti-striated muscle antibodies: predictive value and gain in diagnostic certainty.
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The protein may also be known as CMD1G, CMH9, CMPD4, EOMFC, connectin, and rhabdomyosarcoma antigen MU-RMS-40.14.
CLLennon 67. JBatchelor WLOsserman Bazzigaluppi Adauga in Cos. SKU: IM274 Durata 10 zile* * estimare valabilă doar pentru centrele din București. Different features of mg patients with anti-titin antibodies PM Are there unique autoantigens triggering autoimmune diseases [review]? J Autoimmune response to acetylcholine receptor. Compston JFKoutouzov anti-Titin Antibodies TTN encodes a large abundant protein of striated muscle. It comprises 244 individually folded protein domains connected by unstructured peptide sequences.
Means were compared with the Student The positive predictive value was the proportion of subjects with thymoma among those with positive assay results.
RL Patients with myasthenia gravis and thymoma have in their sera IgG autoantibodies against titin. Labeit CDuclos-Vallee SKolmerer
JFKoutouzov 67.
KMarton Anti-Titin antibodies are available from several suppliers. PCHorst
Lanska et al Quantitative radioligand assays using de novo-synthesized recombinant autoantigens in connective tissue diseases: new tools to approach the pathogenic significance of anti-RNP antibodies in rheumatic diseases.
Data analysis
HJ Antibodies to skeletal muscle in myasthenia gravis, II: prevalence in non-thymoma patients.
JBLimburg JMSeybold